The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

被引:1709
作者
Dibner, Charna [1 ]
Schibler, Ueli [2 ,3 ]
Albrecht, Urs [4 ]
机构
[1] HUG, Div Endocrinol Diabet & Nutr, CH-1211 Geneva 14, Switzerland
[2] Univ Geneva, Dept Mol Biol, CH-1211 Geneva 4, Switzerland
[3] Univ Geneva, NCCR Frontiers Genet, CH-1211 Geneva 4, Switzerland
[4] Univ Fribourg, Dept Med, Div Biochem, CH-1700 Fribourg, Switzerland
关键词
SCN; robustness; circadian synchronization; FEO; MASCO; drugs and rhythms; reward system; circadian metabolism; RAT SUPRACHIASMATIC NUCLEUS; FOOD-ANTICIPATORY ACTIVITY; PERIOD GENE-EXPRESSION; VASOACTIVE-INTESTINAL-PEPTIDE; RETINAL GANGLION-CELLS; INTERGENICULATE LEAFLET; ACTIVITY RHYTHM; TEMPERATURE COMPENSATION; PHOTIC REGULATION; MICE LACKING;
D O I
10.1146/annurev-physiol-021909-135821
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Most physiology and behavior of mammalian organisms follow daily oscillations. These rhythmic processes are governed by environmental cues (e.g., fluctuations in light intensity and temperature), an internal circadian timing system, and the interaction between this timekeeping system and environmental signals. In mammals, the circadian timekeeping system has a complex architecture, composed of a central pacemaker in the brain's suprachiasmatic nuclei (SCN) and subsidiary clocks in nearly every body cell. The central clock is synchronized to geophysical time mainly via photic cues perceived by the retina and transmitted by electrical signals to SCN neurons. In turn, the SCN influences circadian physiology and behavior via neuronal and humoral cues and via the synchronization of local oscillators that are operative in the cells of most organs and tissues. Thus, some of the SCN output pathways serve as input pathways for peripheral tissues. Here we discuss knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system.
引用
收藏
页码:517 / 549
页数:33
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