Primordial germ cells, stem cells and testicular cancer

被引：17

作者：

Donovan, PJ

De Miguel, M

Cheng, LZ

Resnick, JL

机构：

[1] Univ Alcala de Henares, Dept Genet & Cell Biol, Madrid, Spain

[2] Gryphon Pharmaceut, Stem Cell Mol Biol, Baltimore, MD USA

[3] Univ Florida, Dept Microbiol & Mol Genet, Gainesville, FL 32611 USA

来源：

APMIS | 1998年 / 106卷 / 01期

关键词：

germ cells; c-kit/Steel factor; Lif; bFGF; EG cells; teratocarcinoma;

D O I：

10.1111/j.1699-0463.1998.tb01328.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primordial Germ Cells (PGCs) arise in the mouse embryo as a small population of cells some way from the gonad anlagen. In order for the embryo to develop into a fully fertile adult animal the PGCs must increase in number and reach the gonad. Mutations causing sterility in the mouse have identified some of the genes involved in regulating PGC development and some of these genes have been molecularly cloned. Similarly mutations affecting the development and differentiation of PCC-derived tumors (teratomas and teratocarcinomas) have been identified in certain strains of mice and these identify genes involved in the normal growth and differentiation of PGCs. These studies should help to define the role of growth factors in PGC development and in the development of germ-cell-derived tumors.

引用

页码：134 / 141

页数：8

共 46 条

[1] A MUTATION IN THE TER GENE CAUSING INCREASED SUSCEPTIBILITY TO TESTICULAR TERATOMAS MAPS TO MOUSE CHROMOSOME-18 [J].