Transmission of multidrug-resistant HIV-1:: 5 years of immunological and virological survey

被引：7

作者：

Delaugerre, Constance ^{[1
]}

Marcelin, Anne-Genevieve

Soulie, Cathia

Chaix, Marie-Laure

Katlama, Christine

Girard, Pierre-Marie

Calvez, Vincent

Morand-Joubert, Laurence

机构：

[1] Hop Necker Enfants Malad, EA3620, Dept Virol, Paris, France

[2] Hop La Pitie Salpetriere, Dept Virol, EA2387, Paris, France

[3] Hop La Pitie Salpetriere, Dept Infect Dis, Paris, France

[4] Hop St Antoine, APHP, Dept Virol, F-75571 Paris, France

[5] Hop St Antoine, APHP, Dept Infect Dis, F-75571 Paris, France

来源：

AIDS | 2007年 / 21卷 / 10期

关键词：

D O I：

10.1097/QAD.0b013e3280d6edf1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multidrug resistant HIV-1 acquired at the time of primary infection in two patients persisted for at least 5 years with and without treatment. In each patient, only one back mutation to wild-type codon in the protease gene occurred, and that was concomitantly associated with a marked CD4 cell count decrease. In both cases, infection was caused by CCR5 viruses and no rapid clinical progression to AIDS after primary infection was observed.

引用

页码：1365 / 1367

页数：3

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