Statins can inhibit proliferation of human breast cancer cells in vitro

被引：87

作者：

Seeger, H ^{[1
]}

Wallwiener, D ^{[1
]}

Mueck, AO ^{[1
]}

机构：

[1] Univ Tubingen, Dept Obstet & Gynecol, Sect Gynecol Endocrinol & Menopause, D-72076 Tubingen, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2003年 / 111卷 / 01期

关键词：

statins; cell proliferation; human breast cancer cells;

D O I：

10.1055/s-2003-37501

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of five statins, i.e. atorvastatin, fluvastatin, lovastatin, pravastatin and simvastatin was investigated on the proliferation of the human breast cancer cell line MCF-7. All statins except of pravastatin were able to inhibit cell proliferation up to 90% at a concentration of 50 muM. Between the effective statins no significant difference was observed indicating a class-specific effect. These data suggest I hat statins may have clinical significance in the primary prevention of human breast cancer beyond their cholesterol-lowering effect. However, clinical proof must be awaited before drawing any further conclusions.

引用

页码：47 / 48

页数：2

共 10 条

[1]

ANDREOTTI PE, 1991, BIOLUMINESCENCE AND CHEMILUMINESCENCE, P417

[2] Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines:: an in vitro study [J].