Intranasal cowpox virus infection of the mouse as a model for preclinical evaluation of smallpox vaccines

被引：16

作者：

Ferrier-Rembert, Audrey

Drillien, Robert

Tournier, Jean-Nicolas

Garin, Daniel

Crance, Jean-Marc

机构：

[1] Ctr Rech Serv Sante Armees, Unite Virol, F-38702 Grenoble, France

[2] CNRS, UMR7104, INSERM, IGBMC,U596, F-67404 Illkirch Graffenstaden, France

[3] Univ Strasbourg, F-67000 Strasbourg, France

来源：

VACCINE | 2007年 / 25卷 / 25期

关键词：

mouse model; smallpox vaccine; cowpox virus;

D O I：

10.1016/j.vaccine.2007.04.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intranasal infection of mice with cowpox virus (CPXV) has been evaluated as a model for smallpox infection in man. Administration of a lethal dose of CPXV allowed time for development of T-cell responses but antibodies could not be detected before death occurred. In contrast, infection with a sublethal dose was associated with an early T-cell response followed by neutralising antibodies which correlated with virus clearance. Comparison of two first generation smallpox vaccines revealed no significant differences in terms of immunogenicity, protection and post-challenge virus clearance. These studies show that the CPXV/mouse model is valuable for the initial assessment of smallpox vaccines. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4809 / 4817

页数：9

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