Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies

被引：69

作者：

Sahoo, Anasuya ^{[1
]}

Yabanoglu, Samiye ^{[2
]}

Sinha, Barij N. ^{[1
]}

Ucar, Gulberk ^{[2
]}

Basu, Arijit ^{[1
]}

Jayaprakash, Venkatesan ^{[1
]}

机构：

[1] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi 835215, Bihar, India

[2] Hacettepe Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 01期

关键词：

Pyrazolines; MAO-inhibitors; Docking; BRAIN MONOAMINE-OXIDASE; 1-N-SUBSTITUTED THIOCARBAMOYL-3-PHENYL-5-THIENYL-2-PYRAZOLINES; ANTIDEPRESSANT ACTIVITIES; B INHIBITORS; DERIVATIVES; TRENDS;

D O I：

10.1016/j.bmcl.2009.11.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten novel 3,5-diaryl pyrazolines were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. All the molecules were found to be reversible and selective inhibitor for either one of the isoform (MAO-A or MAO-B). Further insights in the theoretical evaluation of the possible interactions between the compounds and monoamine oxidases (MAO-A or MAO-B) have been developed through docking studies. The theoretical values are in congruence with their experimental values. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：132 / 136

页数：5

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