Catalytic enantioselective intermolecular cycloadditions of a 2-diazo-3,6-diketoester-derived carbonyl ylide with alkyne and strained alkene dipolarophiles

被引：29

作者：

Hodgson, DM

Labande, AH

Glen, R

Redgrave, AJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

[2] GlaxoSmithKline Med Res Ctr, Resp & Inflammat CEDD, Med Chem 1, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(03)00036-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Catalytic enantioselective tandem carbonyl ylide formation-cycloaddition reactions of tert-butyl 2-diazo-3,6-dioxoheptanoate 7 with alkyne and strained alkene dipolarophiles to afford the corresponding cycloadducts with up to 92% ee are described. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：921 / 924

页数：4

共 26 条

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