Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study

被引：113

作者：

Miyachi, K

Hankins, RW

Matsushima, H

Kikuchi, F

Inomata, T

Horigome, T

Shibata, M

Onozuka, Y

Ueno, Y

Hashimoto, E

Hayashi, N

Shibuya, A

Amaki, S

Miyakawa, H

机构：

[1] Htlh Sci Res Inst Inc, Diagnost Div 1, Hodogaya Ku, Kanagawa 2400005, Japan

[2] Niigata Univ, Fac Sci, Niigata 95021, Japan

[3] Kanto Med Ctr NTT EC, Dept Gastroenterol, Tokyo, Japan

[4] Kawasaki Soc Insurance Hosp, Dept Internal Med, Kawasaki, Kanagawa, Japan

[5] Tokyo Womens Med Coll, Dept Gastroenterol, Tokyo, Japan

[6] Kitasato Univ, Sch Med, Dept Internal Med, Tokyo, Japan

[7] Nihon Univ, Sch Med, Dept Internal Med 3, Tokyo 102, Japan

[8] Teikyo Univ, Mizonokuchi Hosp, Dept Internal Med 4, Tokyo, Japan

来源：

JOURNAL OF AUTOIMMUNITY | 2003年 / 20卷 / 03期

关键词：

anti-nuclear envelope antibody; anti-p62 complex antibody; primary biliary cirrhosis;

D O I：

10.1016/S0896-8411(03)00033-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Primary biliary cirrhosis (PBC) sera contain antibodies which recognize various nuclear envelope proteins of which antibody against gp210 has been proven to be diagnostic for disease. In contrast, the clinical significance of another nuclear envelope antibody, anti-p62 antibody has not been well investigated. In the present study, we have analyzed anti-nuclear envelope antibodies by indirect immunofluorescence and immunoblot using rat liver nuclear envelope proteins and wheat germ agglutinin-bound fraction. Test sera were obtained from 175 patients with PBC and from 120 controls. Anti-gp210, anti-lamina associated polypeptide 2. anti-lamin B receptor, and anti-p62 complex antibodies were detected with a frequency of 26%, (46 of 175), 6%, (11 of 175), 9% (16 of 175), and 13% (15 of 115), respectively. The confirmation of Scheuer's stage IV was made with a frequency of 27% (4 of 15) in PBC patients with anti-p62 complex antibody, in contrast to only 2% (2 of 100) in PBC patients without anti-p62 complex antibody. This difference was found to be statistically significant. The presence of anti-p62 complex antibody may be related with the progressive or advanced state of PBC. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：247 / 254

页数：8

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