Genetic selection for resistance or susceptibility to oral tolerance to ovalbumin affects general mechanisms of tolerance induction in mice

被引：5

作者：

Kamphorst, AO

da Silva, MFS

da Silva, AC

Carvalho, CR

Faria, AMC

机构：

[1] Univ Fed Minas Gerais, ICB, Dept Quim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

[2] UERJ, IB, Dept Biol Celular & Genet, Rio De Janeiro, Brazil

[3] Univ Fed Minas Gerais, ICB, Dept Morfol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION | 2004年 / 1029卷

关键词：

genetic selection; oral tolerance; immunoregulation; continuous feeding; TS mice; TR mice;

D O I：

10.1196/annals.1309.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To study the genes involved in oral tolerance susceptibility, two strains of mice were genetically selected for susceptibility (TS) and resistance (TR) to oral tolerance to ovalbumin by bidirectional breeding. Herein we show that the genetic selection process is restricted neither to ovalbumin nor to oral tolerance. It affected oral tolerance to other proteins, such as casein, and tolerance induced the intravenous route.

引用

页码：350 / 354

页数：5

共 6 条

[1] Genetics of immunological tolerance: I. Bidirectional selective breeding of mice for oral tolerance [J].