Signaling degradation

被引：4

作者：

Kenniston, JA ^{[1
]}

Sauer, RT ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 09期

关键词：

D O I：

10.1038/nsmb0904-800

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many proteins are marked for destruction by covalent attachment of a polyubiquitin chain that directs binding of the modified molecule to the proteasome. A new report demonstrates that an unstructured region of the substrate must also be recognized to begin proteolytic engagement.

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页码：800 / 802

页数：3

相关论文

共 21 条

[1]

BERCOVICH Z, 1989, J BIOL CHEM, V264, P15949

[2] The base of the proteasome regulatory particle exhibits chaperone-like activity [J].

Braun, BC ;

Glickman, M ;

Kraft, R ;

Dahlmann, B ;

Kloetzel, PM ;

Finley, D ;

Schmidt, M .

NATURE CELL BIOLOGY, 1999, 1 (04) :221-226

[3] AAA plus proteins and substrate recognition, it all depends on their partner in crime [J].

Dougan, DA ;

Mogk, A ;

Zeth, K ;

Turgay, K ;

Bukau, B .

FEBS LETTERS, 2002, 529 (01) :6-10

[4] Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals [J].

Flynn, JM ;

Neher, SB ;

Kim, YI ;

Sauer, RT ;

Baker, TA .

MOLECULAR CELL, 2003, 11 (03) :671-683

[5] A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3 [J].

Glickman, MH ;

Rubin, DM ;

Coux, O ;

Wefes, I ;

Pfeifer, G ;

Cjeka, Z ;

Baumeister, W ;

Fried, VA ;

Finley, D .

CELL, 1998, 94 (05) :615-623

[6] The ubiquitin system [J].

Hershko, A ;

Ciechanover, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :425-479

[7] Localization to the proteasome is sufficient for degradation [J].

Janse, DM ;

Crosas, B ;

Finley, D ;

Church, GM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (20) :21415-21420

[8] Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA [J].

Keiler, KC ;

Waller, PRH ;

Sauer, RT .

SCIENCE, 1996, 271 (5251) :990-993

[9] Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine [J].

Kenniston, JA ;

Baker, TA ;

Fernandez, JM ;

Sauer, RT .

CELL, 2003, 114 (04) :511-520

[10] ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal [J].

Lee, C ;

Schwartz, MP ;

Prakash, S ;

Iwakura, M ;

Matouschek, A .

MOLECULAR CELL, 2001, 7 (03) :627-637