Postexposure Treatment of Marburg Virus Infection

被引：66

作者：

Geisbert, Thomas W. ^{[1
]}

Hensley, Lisa E. ^{[2
]}

Geisbert, Joan B.

Leung, Anders ^{[3
]}

Johnson, Joshua C. ^{[2
]}

Grolla, Allen ^{[3
]}

Feldmann, Heinz ^{[4
]}

机构：

[1] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA

[2] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA

[3] Publ Hlth Agcy Canada, Winnipeg, MB, Canada

[4] NIH, Hamilton, MT USA

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 07期

基金：

美国国家卫生研究院;

关键词：

EBOLA HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; PROTECTION; VECTORS;

D O I：

10.3201/eid1607.100159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus-based vaccine is administered 20-30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.

引用

页码：1119 / 1122

页数：4

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