Effect of Rheum emodi (Revand Hindi) on renal functions in rats

被引：40

作者：

Alam, MMA

Javed, K

Jafri, MA ^{[1
]}

机构：

[1] Jamia Hamdard, Fac Med U, Dept Ilmul Advia, New Delhi 110062, India

[2] Jamia Hamdard, Fac Med, Dept Chem, New Delhi 110062, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 96卷 / 1-2期

关键词：

nephroprotective; heavy metals; aminoglycosides; rhubarb; rheum; renal disorders;

D O I：

10.1016/j.jep.2004.08.028

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The renal effects of water-soluble (W-S) and water-insoluble (W-INS) portions of the alcoholic extract of Revand Hindi (Rheum emodi) were investigated on cadmium chloride, mercuric chloride, potassium dichromate and gentamicin-induced nephrotoxicity in rats and normal rats by monitoring the levels of urea nitrogen and creatinine in serum. The present investigations provide evidences that W-S fraction has nephroprotective effect on all the proximal tubule segments (S-1, S-2 and S-3) possibly through antioxidant action of the tannins present in the fraction. W-INS also improved the renal function by protecting S-2 segment of proximal tubule nephrotoxicity induced by metals viz cadmium chloride and mercuric chloride in rat models, however, this fraction has been found to enhance gentamicin nephrotoxicity. (C) 2004 Published by Elsevier Ireland Ltd.

引用

页码：121 / 125

页数：5

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