Cytokine-secreting tumor cell vaccines

被引：104

作者：

Mach, N ^{[1
]}

Dranoff, G ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(00)00144-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.

引用

页码：571 / 575

页数：5

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