Psychosocial contributors to mental and physical health in patients with systemic lupus erythematosus

Objective. To delineate psychosocial and systemic lupus erythematosus (SLE)-related medicalfactors that contribute to the mental and physical health of SLE patients. Methods. In a cross-sectional study, 44 women completed standardized instruments assessing daily hassles, social support, psychologic distress, and quality of life and underwent a physician examination to assess disease activity and disease damage. Four multiple linear regression analyses were computed to identify factors associated with the following outcomes: patient-perceived psychologic distress and global physical health and physician-assessed disease activity and damage. Variables entered into the regression analyses were: hassles severity, types of social support, SLE disease activity and damage, age, disease duration, education, ethnicity, and global psychologic distress (for the outcomes of self-perceived global physical health and disease activity and damage). Results. The best model explaining global psychologic distress included hassles severity and self-esteem social support. The best model explaining patients' perceptions of their global physical health included hassles severity and tangible social support. Psychologic distress accounted for a significant proportion of variance in both disease activity and damage. Conclusion. High stress (assessed by hassles severity), poor social support, and psychologic distress-potentially modifiable variables-are associated with the mental and physical health of SLE patients.