Neurodegeneration - Chaperoning brain diseases

被引：73

作者：

Welch, WJ ^{[1
]}

Gambetti, P

机构：

[1] Univ Calif San Francisco, Dept Surg Med & Physiol, San Francisco, CA 94143 USA

[2] Case Western Reserve Univ, Inst Pathol, Div Neuropathol, Cleveland, OH 44106 USA

来源：

NATURE | 1998年 / 392卷 / 6671期

关键词：

D O I：

10.1038/32049

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prion diseases and neurodegenerative conditions such as Alzheimer's and Parkinson's have much in common — both seem to involve proteins which, when destabilized by (for example) genetic mutations, change conformation to form insoluble, pathogenic aggregates. Two papers now ask whether molecular chaperones might be involved in these folding changes, and they show that heat-shock proteins and prions can, indeed, interact in vitro.

引用

页码：23 / 24

页数：2

共 16 条

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