Protein tyrosine phosphatases and the immune response

被引：278

作者：

Mustelin, T

Vang, T

Bottini, N

机构：

[1] Burnham Inst, Program Inflammat, Inflammatory & Infect Dis Ctr, La Jolla, CA 92037 USA

[2] Burnham Inst, Program Signal Transduct, Ctr Canc, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1530

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases. Together, cells of the immune system express at least half of the 107 protein tyrosine phosphatase (PTP) genes in the human genome, most of which encode multidomain proteins that contain protein- and phospholipid-interaction domains. Here, we discuss the diverse but specific, and important, roles that PTPs have in immune cells, focusing mainly on T and B cells, and we highlight recent evidence that even subtle alterations in PTPs can cause immune dysfunction and human disease.

引用

页码：43 / 57

页数：15

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