The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

被引：919

作者：

Sakurai, Takeshi ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Japan

[2] Japan Sci & Technol Agcy, ERATO, Yanagisawa Orphan Receptor Project, Tokyo 1350064, Japan

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 03期

关键词：

D O I：

10.1038/nrn2092

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments. Avoiding danger and finding food, which are life-essential activities that are regulated by emotion, reward and energy balance, require vigilance and therefore, by definition, wakefulness. The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis.

引用

页码：171 / 181

页数：11

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