Effects of ethanol on the inner layers of chick retina during development

被引：28

作者：

Chmielewski, CE ^{[1
]}

Hernandez, LM ^{[1
]}

Quesada, A ^{[1
]}

Pozas, JA ^{[1
]}

Picabea, L ^{[1
]}

Prada, FA ^{[1
]}

机构：

[1] UNIV SEVILLA,FAC MED,DEPT BIOQUIM BROMATOL & TOXICOL,SEVILLE 41009,SPAIN

来源：

ALCOHOL | 1997年 / 14卷 / 04期

关键词：

fetal alcohol syndrome; hypoplasia; optic nerve;

D O I：

10.1016/S0741-8329(97)87948-7

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Optic nerve hypoplasia is an important malformation of the fetal alcohol syndrome whose teratogenic mechanisms are unknown. In our experimental model we have quantified the concentration of ethanol and acetaldehyde in the retina and vitreous humor of the developing chick. The effect of ethanol alone during retinal development was analysed by conventional histological techniques and by immunostaining. A single injection of ethanol in the vitelline sac at the beginning of retinal cell differentiation retarded synaptogenesis in the inner plexiform layer and produced abundant ganglion cell death and a sharp diminution of myelinic axons. Our observations could help to explain certain alterations described in children exposed to ethanol during the development of their nervous system. (C) 1997 Elsevier Science Inc.

引用

页码：313 / 317

页数：5

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