Prebiotic oligosaccharides in dietetic products for infants: A commentary by the ESPGHAN committee on nutrition

被引:67
作者
Agostoni, C
Axelsson, T
Goulet, O
Koletzko, B
Michaelsen, KF
Puntis, JWL
Rigo, J
Shamir, R
Szajewska, H
Turck, D
机构
[1] Med Univ Warsaw, Dept Pediat Gastroenterol & Nutr, PL-01184 Warsaw, Poland
[2] Univ Milan, Milan, Italy
[3] Lund Univ, Lund, Sweden
[4] Hop Necker Enfants Malad, Paris, France
[5] Univ Munich, Munich, Germany
[6] Royal Vet & Agr Univ, Frederiksberg, Denmark
[7] Gen Infirm, Leeds LS1 3EX, W Yorkshire, England
[8] Univ Liege, Liege, Belgium
[9] Meyers Childrens Hosp, Haifa, Israel
[10] Univ Lille, Lille, France
关键词
infant nutrition; infant formula; prebiotics;
D O I
10.1097/00005176-200411000-00003
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
This article by the ESPGHAN Committee on Nutrition summarizes available information on the effects of adding prebiotic oligosaccharides to infant and follow-on formulae. Currently there are only limited studies evaluating prebiotic substances in dietetic products for infants. Although administration of prebiotic oligosaccharides has the potential to increase the total number of bifidobacteria in feces and may also soften stools, there is no published evidence of clinical benefits of adding prebiotic oligosaccharides to dietetic products for infants. Data on oligosaccharide mixtures in infant formulae do not demonstrate adverse effects, but further evaluation is recommended. Combinations and dosages in addition to those so far studied need to be fully evaluated with respect to both safety and efficacy before their use in commercial infant food products. Well-designed and carefully conducted randomized controlled trials with relevant inclusion/exclusion criteria, adequate sample sizes and validated clinical outcome measures are needed both in preterm and term infants. Future trials should define optimal quantity and types of oligosaccharides with prebiotic function, optimal dosages and duration of intake, short and long term benefits and safety. At the present time, therefore, the Committee takes the view that no general recommendation on the use of oligosaccharide supplementation in infancy as a prophylactic or therapeutic measure can be made.
引用
收藏
页码:465 / 473
页数:9
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