Spatial organization, predictability, and determinism in ventricular fibrillation

被引:28
作者
Bayly, PV
KenKnight, BH
Rogers, JM
Johnson, EE
Ideker, RE
Smith, WM
机构
[1] Washington Univ, St Louis, MO 63130 USA
[2] Guidant Corp, St Paul, MN 55112 USA
[3] Univ Alabama Birmingham, Birmingham, AL 35294 USA
[4] Cardiol Grp, Memphis, TN 38103 USA
关键词
D O I
10.1063/1.166291
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
The degree of spatial organization of ventricular fibrillation (VF) is a fundamental dynamical property of the arrhythmia and may determine the success of proposed therapeutic approaches. Spatial organization is closely related to the dimension of VF, and hence to its predictability and controllability. We have explored several techniques to quantify spatial organization during VF, to predict patterns of activity, and to see how spatial organization and predictability change as the arrhythmia progresses. Epicardial electrograms recorded from pig hearts using rectangular arrays of unipolar extracellular electrodes (1 mm spacing) were analyzed. The correlation length of VF, the number of Karhunen-Loeve modes required to approximate data during VF, the number, size and recurrence of wavefronts, and the mean square error of epicardial potential fields predicted 0.256 seconds into the future were all estimated. The ability of regularly-timed pacing stimuli to capture areas of fibrillating myocardium during VF was confirmed by a significant increase in local spatial organization. Results indicate that VF is neither "low-dimensional chaos" (dimension <5) nor "random" behavior (dimension=infinity), but is a high-dimensional response with a degree of spatial coherence that changes as the arrhythmia progresses. (C) 1998 American Institute of Physics.
引用
收藏
页码:103 / 115
页数:13
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