Influence of free chains on the swelling pressure of PEG-HEMA and dex-HEMA hydrogels

被引：10

作者：

Van Thienen, T. G.

Horkay, F.

Braeckmans, K.

Stubbe, B. G.

Demeester, J.

De Smedt, S. C.

机构：

[1] Univ Ghent, Dept Pharmaceut, Lab Gen Biochem & Phys Pharm, B-9000 Ghent, Belgium

[2] NICHD, Sect Tissue Biophys & Biomimet, Lab Integrat & Med Biophys, NIH, Bethesda, MD 20892 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2007年 / 337卷 / 1-2期

关键词：

drug delivery; biodegradable hydrogels; swelling pressure; osmotic pressure; CONTROLLED-RELEASE; DELIVERY; DEXTRAN; DEGRADATION; GELS; EQUILIBRIUM; CONJUGATE; NETWORKS; BEHAVIOR; SCAFFOLD;

D O I：

10.1016/j.ijpharm.2006.12.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Insight in the osmotic behavior of degrading hydrogels is of great importance in the design of biodegradable hydrogels forbiornedical applications. This study compares the degradation behavior of PEG-HEMA (hydroxyethylmethacrylated polyethylene glycol) and dex-HEMA (hydroxyethylmethacrylated dextran) hydrogels. The degradation of PEG-HEMA gels takes several months to over a year, while that of dex-HEMA gels takes only days or weeks. The faster degradation kinetics of dex-HEMA networks can be attributed to stabilization of the keto-enol form by hydroxyl groups. Upon degradation of PEG-HEMA and dex-HEMA hydrogels, respectively, free PEG and free dextran chains are produced. We investigated the effect of unattached PEG and dextran chains on the swelling pressure of the degrading gels. It is found that low molecular weight free chains significantly increase the swelling pressure. However, the contribution of higher molecular weight free chains (M-w > 10kDa) is similar to that of the network chains. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：31 / 39

页数：9

共 42 条

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