Quantifying HTLV-I dynamics

被引：64

作者：

Asquith, Becca ^{[1
]}

Bangham, Charles R. M. ^{[1
]}

机构：

[1] Imperial Coll, Dept Immunol, London W2 1PG, England

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2007年 / 85卷 / 04期

关键词：

HTLV-1; HIV-1; mathematical model; kinetics; cytotoxic T lymphocytes;

D O I：

10.1038/sj.icb.7100050

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite significant advances in our understanding of the immune response to persistent viruses like human T-cell lymphotropic virus type I (HTLV-I), many important questions remain unanswered. Mathematical modelling enables us to interpret and synthesise diverse experimental data in new ways and thus can contribute to our understanding. Here, we review recent advances in mathematical modelling of HTLV-I infection and illustrate how mathematics has enabled us to identify factors that determine an individual's viral burden and risk of developing HTLV-I-associated diseases.

引用

收藏

页码：280 / 286

页数：7

相关论文

共 46 条

[1] Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo [J].

Asquith, B ;

Edwards, CTT ;

Lipsitch, M ;

McLean, AR .

PLOS BIOLOGY, 2006, 4 (04) :583-592

[2] A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load [J].

Asquith, B ;

Mosley, AJ ;

Barfield, A ;

Marshall, SEF ;

Heaps, A ;

Goon, P ;

Hanon, E ;

Tanaka, Y ;

Taylor, GP ;

Bangham, CRM .

JOURNAL OF GENERAL VIROLOGY, 2005, 86 :1515-1523

[3] Quantification of the virus-host interaction in human T lymphotropic virus I infection [J].

Asquith, B ;

Mosley, AJ ;

Heaps, A ;

Tanaka, Y ;

Taylor, GP ;

McLean, AR ;

Bangham, CRM .

RETROVIROLOGY, 2005, 2 (1)

[4] HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes [J].

Collins, KL ;

Chen, BK ;

Kalams, SA ;

Walker, BD ;

Baltimore, D .

NATURE, 1998, 391 (6665) :397-401

[5] Turnover rates of B cells, T cells, and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques [J].

De Boer, RJ ;

Mohri, H ;

Ho, DD ;

Perelson, AS .

JOURNAL OF IMMUNOLOGY, 2003, 170 (05) :2479-2487

[6] Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection [J].

Draenert, R ;

Le Gall, S ;

Pfafferott, KJ ;

Leslie, AJ ;

Chetty, P ;

Brander, C ;

Holmes, EC ;

Chang, SC ;

Feeney, ME ;

Addo, MM ;

Ruiz, LD ;

Ramduth, D ;

Jeena, P ;

Altfeld, M ;

Thomas, S ;

Tang, TH ;

Verrill, CL ;

Dixon, C ;

Prado, JG ;

Kiepiela, P ;

Martinez-Picado, J ;

Walker, BD ;

Goulder, PJR .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (07) :905-915

[7] HIV replication elicits little cytopathic effects little cytopathic effects in vivo:: Analysis of surrogate markers for virus production, cytotoxic T cell response and infected cell death [J].

Funk, Georg A. ;

Oxenius, Annette ;

Fischer, Marek ;

Opravil, Milos ;

Joos, Beda ;

Flepp, Markus ;

Weber, Rainer ;

Guenthard, Huldrych F. ;

Bonhoeffer, Sebastian .

JOURNAL OF MEDICAL VIROLOGY, 2006, 78 (09) :1141-1146

[8] Human T cell lymphotropic virus (HTLV) type-1-specific CD8+ T cells:: Frequency and immunodominance hierarchy [J].

Goon, PKC ;

Biancardi, A ;

Fast, N ;

Igakura, T ;

Hanon, E ;

Mosley, AJ ;

Asquith, B ;

Gould, KG ;

Marshall, S ;

Taylor, GP ;

Bangham, CRM .

JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (12) :2294-2298

[9] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[10]

Höllsberg P, 1999, MICROBIOL MOL BIOL R, V63, P308

← 1 2 3 4 5 →