Treatment of heart failure with beta-blockers.: Mechanisms and results

被引：32

作者：

Böhm, M ^{[1
]}

Maack, C ^{[1
]}

机构：

[1] Univ Saarlandes, Med Klin & Poliklin, D-66421 Homburg, Germany

来源：

BASIC RESEARCH IN CARDIOLOGY | 2000年 / 95卷 / Suppl 1期

关键词：

chronic heart failure; neuroendocrine activation; beta-adrenergic receptors; signal transduction; medical therapy;

D O I：

10.1007/s003950070004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sympathetic activation is a significant predictor of a poor prognosis in heart failure. Excessive stimulation with norepinephrine produces apoptosis,tachycardia and arrhythmias thereby leading to progression of left ventricular dysfunction and worsening of outcome. beta -Blockers reduce morbidity and improve cardiac function. They have been shown to improve survival (MERIT-HF, CIBIS II and US-Carvedilol Trials). A careful uptitration of dosages is achievable with a low rate of side effects. The mechanism of beta -blocker effects in heart failure are cardiac protection from beta1-adrenoceptor overstimulation, antiarrhythmic effects, reduction in heart rate and positive energetic effects or a combination thereof.

引用

页码：15 / 24

页数：10

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