New furostanol saponins from Allium ascalonicum L.

被引：28

作者：

Kang, Li-Ping

Liu, Zhi-Jun

Zhang, Lei

Tan, Da-Wei

Zhao, Yang

Zhao, Yu

Chen, He-Bing

Ma, Bai-Ping ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Beijing 100850, Peoples R China

[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210038, Peoples R China

[3] China Acad TCM, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[4] Natl Ctr Biomed Anal, Beijing 100850, Peoples R China

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2007年 / 45卷 / 09期

关键词：

Allitum ascalonicum L; furostanol saponins; NMR; ascalonicoside C; ascalonicoside D; STEROIDAL SAPOGENINS; NMR-SPECTROSCOPY; RHIZOMES;

D O I：

10.1002/mrc.2037

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An analysis of the polar extracts from Allium ascalonicum L. led to the isolation of two new furostanol saponins (compound 1 and 2) and two known furostanol saponins (compound 3 and 4). On the basis of 1D and 2D NMR (including H-1, C-13 NMR, H-1-H-1 COSY, HSQC, TOCSY, HMBC, and NOESY), FAB-MS spectrometry, and chemical methods, their structures were elucidated as (25R)-26-O-beta-D-glucopyranosyl-22-hydroxy-5 alpha-furost-2-one-3 beta, 5, 6 beta, 26-tetraol-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (ascalonicoside C, 1), (25R)-26-O-beta-D-glucopyranosyl-22-methoxy-5 alpha-furost-2-one-3 beta, 5, 6 beta, 26-tetraol-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (ascalonicoside D, 2), (25R)-26-O-,beta-D-glucopyranosyl-22-hydroxy-5-ene-furostan-3 beta, 26-diol-3-O-alpha-L-rhamnopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 4)-[alpha-L-rhamnopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (dichotomin, 3), and (25R)-26-O-beta-D-glucopyranosyl-22-hydroxy-5-ene-furostan-3 beta, 26-diol-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-arabinofuranosyl-(1 -> 4)]-beta-D-glucopyranoside (parisaponin I, 4). Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：725 / 733

页数：9

共 18 条

[1] Dependence of 1H NMR chemical shifts of geminal protons of glycosyloxy methylene (H2-26) on the orientation of the 27-methyl group of furostane-type steroidal saponins [J].