The pH of the secretory pathway: Measurement, determinants, and regulation

被引：362

作者：

Paroutis, P ^{[1
]}

Touret, N ^{[1
]}

Grinstein, S ^{[1
]}

机构：

[1] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

来源：

PHYSIOLOGY | 2004年 / 19卷

关键词：

D O I：

10.1152/physiol.00005.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The luminal pH of the secretory pathway plays a critical role in the posttranslational modification and sorting of proteins and lipids. The pH of each one of the organelles that constitute the pathway is unique, becoming more acidic as the biosynthetic cargo approaches its destination. The methods used for measurement of pH in the secretory pathway, its determinants, and its regulation are the subjects of this review,

引用

页码：207 / 215

页数：9

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