Microtubules are an intracellular target of the plant terpene citral

被引：70

作者：

Chaimovitsh, David ^{[1
,2
]}

Abu-Abied, Mohamad ^{[3
]}

Belausov, Eduard ^{[3
]}

Rubin, Baruch ^{[2
]}

Dudai, Nativ ^{[1
]}

Sadot, Einat ^{[3
]}

机构：

[1] Agr Res Org, Div Aromat Plants, IL-30095 Ramat Yishai, Israel

[2] Hebrew Univ Jerusalem, RH Smith Inst Plant Sci & Genet Agr, Fac Agr Food & Environm Sci, IL-76100 Rehovot, Israel

[3] Agr Res Org, Inst Plant Sci, Volcani Ctr, IL-50250 Bet Dagan, Israel

来源：

PLANT JOURNAL | 2010年 / 61卷 / 03期

关键词：

citral; microtubules; actin; essential oil; Arabidopsis; ESSENTIAL OILS; DINITROANILINE HERBICIDE; APICAL MERISTEM; CELL-DEATH; IN-VIVO; APOPTOSIS; GROWTH; CYTOSKELETON; INDUCTION; TUBULIN;

D O I：

10.1111/j.1365-313X.2009.04063.x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Citral is a component of plant essential oils that possesses several biological activities. It has known medicinal traits, and is used as a food additive and in cosmetics. Citral has been suggested to have potential in weed management, but its precise mode of action at the cellular level is unknown. Here we investigated the immediate response of plant cells to citral at micromolar concentrations. It was found that microtubules of Arabidopsis seedlings were disrupted within minutes after exposure to citral in the gaseous phase, whereas actin filaments remained intact. The effect of citral on plant microtubules was both time- and dose-dependent, and recovery only occurred many hours after a short exposure of several minutes to citral. Citral was also able to disrupt animal microtubules, albeit less efficiently. In addition, polymerization of microtubules in vitro was inhibited in the presence of citral. Taken together, our results suggest that citral is a potent, volatile, anti-microtubule compound.

引用

页码：399 / 408

页数：10

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