Cyclotides: macrocyclic peptides with applications in drug design and agriculture

被引：60

作者：

Craik, David J. ^{[1
]}

Mylne, Joshua S. ^{[1
]}

Daly, Norelle L. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 01期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Circular proteins; Cyclic cystine knot; Cyclisation; Kalata B1; BACKBONE-CYCLIZED PEPTIDES; POLYPEPTIDE KALATA B1; CYSTINE-KNOT; PLANT CYCLOTIDES; CIRCULAR PROTEINS; OLDENLANDIA-AFFINIS; CHEMICAL-SYNTHESIS; CYCLOVIOLACIN O2; MEMBRANE INTERACTION; SPATIAL STRUCTURE;

D O I：

10.1007/s00018-009-0159-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclotides are disulfide-rich peptides from plants that are exceptionally stable as a result of their unique cyclic cystine knot structural motif. Their natural role is thought to be as plant defence agents, most notably against insect pests, but they also have potential applications in drug design and agriculture. This article identifies gaps in current knowledge on cyclotides and suggests future directions for research into this fascinating family of ultra-stable mini-proteins.

引用

页码：9 / 16

页数：8

共 74 条

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