Cytotoxic triterpenoid saponins from Symplocos chinensis

被引：33

作者：

Tang, MJ

Shen, DD

Hu, YC

Gao, S

Yu, SS ^{[1
]}

机构：

[1] Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 12期

关键词：

D O I：

10.1021/np040013g

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Six new triterpenoid saponins were isolated as methyl or butyl esters from an n-BuOH extract of the roots of Symplocos chinensis. Their structures were established as symplocososides A (1), B (2), C (3), D (4), E (5), and F (6), by extensive 1D and 2D NMR as well as HR-MS analysis and chemical methods. Compounds 1, 3, and 6 were cytotoxic against one or more cell lines, and the derivative from 1 (1d) showed significant selectivities between KB cells and normal cells.

引用

页码：1969 / 1974

页数：6

共 9 条

[1]

ABE F, 1987, CHEM PHARM BULL, V35, P1748

[2]

ITIRO Y, 1972, CHEM PHARM BULL, V20, P1499

[3]

SAPONINS FROM STEM BARK OF PETERSIANTHUS-MACROCARPUS [J].

MASSIOT, G ;

CHEN, XF ;

LAVAUD, C ;

LEMENOLIVIER, L ;

DELAUDE, C ;

VIARI, A ;

VIGNY, P ;

DUVAL, J .

PHYTOCHEMISTRY, 1992, 31 (10) :3571-3576

[4]

Petersaponins III and IV, triterpenoid saponins from Petersianthus macrocarpus [J].

Olugbade, TA ;

Ogundaini, A ;

Birlirakis, N ;

Païs, M ;

Martin, MT .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (05) :716-719

[5]

RYUICHI O, 1980, CHEM LETT, V19, P1825

[6]

AESCULUSIDE-B, A NEW TRITERPENE GLYCOSIDE FROM AESCULUS-INDICA [J].

SINGH, B ;

AGRAWAL, PK ;

THAKUR, RS .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (05) :781-783

[7]

TAKAO K, 1986, J NAT PRODUCTS, V49, P650

[8]

YI L, 2000, PHYTOCHEMISTRY, V53, P941

[9]

YU DQ, 1999, ANAL CHEM HDB, V7, P754

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