Perinatal group B streptococcal disease

被引:82
作者
Heath, Paul T. [1 ]
Schuchat, Anne
机构
[1] Univ London St Georges Hosp, Vaccine Inst, London SW17 0RE, England
[2] Univ London St Georges Hosp, Div Child Hlth, London SW17 0RE, England
[3] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA
关键词
streptococcus agralactiae; group B streptococcus; prevention; infant; vaccine;
D O I
10.1016/j.bpobgyn.2007.01.003
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Group B streptococcus (GBS) is the leading cause of neonatal sepsis and meningitis. Despite optimal treatment of GBS-infected neonates it is associated with significant morbidity and mortality, and prevention strategies are required. As disease occurs rapidly, and is often evident at birth or within 12 hours of birth, antibiotics must be given prior to delivery, and when administered early enough, and at the correct doses, they will prevent the majority of early-onset GBS cases. Prevention is therefore in the hands of obstetricians and midwives. Women at higher risk of delivering infected infants can be identified through one of two strategies: the presence of one or more clinical risk factors, or the presence of GBS on lower vaginal/rectal swabs obtained late in pregnancy. Decisions on which strategy to use will depend on a number of factors. A swab-based approach appears to have higher efficacy but is likely to lead to more antibiotic exposure.
引用
收藏
页码:411 / 424
页数:14
相关论文
共 85 条
  • [1] ACOG committee opinion, 1996, INT J GYNECOL OBSTET, V54, P197, DOI DOI 10.1016/S0020-7292(96)90083-1
  • [2] PERINATAL GROUP-B STREPTOCOCCAL COLONIZATION AND INFECTION
    ALLARDICE, JG
    BASKETT, TF
    SESHIA, MMK
    BOWMAN, N
    MALAZDREWICZ, R
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1982, 142 (06) : 617 - 620
  • [3] American College of Obstetricians and Gynecologists, 2002, Obstet Gynecol, V100, P1405
  • [4] [Anonymous], 1996, MMWR Recomm Rep, V45, P1
  • [5] [Anonymous], 1992, Pediatrics, V90, P775
  • [6] [Anonymous], 1985, Br Med J (Clin Res Ed), V290, P778
  • [7] [Anonymous], ANN I PASTEUR
  • [8] Early-onset neonatal sepsis in the era of group B streptococcal prevention
    Baltimore, RS
    Huie, SM
    Meek, JI
    Schuchat, A
    O'Brien, KL
    [J]. PEDIATRICS, 2001, 108 (05) : 1094 - 1098
  • [9] GROUP-B BETA HEMOLYTIC STREPTOCOCCAL MENINGITIS IN INFANTS
    BARTON, LL
    FEIGIN, RD
    LINS, R
    [J]. JOURNAL OF PEDIATRICS, 1973, 82 (04) : 719 - 723
  • [10] Neonatal group B streptococcal infection in South Bedfordshire, 1993-1998
    Beardsall, K
    Thompson, MH
    Mulla, RJ
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2000, 82 (03): : F205 - F207