The role of nuclear import and export in influenza virus infection

被引:99
作者
Whittaker, G
Bui, M
Helenius, A
机构
[1] Dept of Cell Biology, Yale University School of Medicine, New Haven
关键词
D O I
10.1016/0962-8924(96)81017-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Infection with influenza virus involves a complex series of nuclear import and export events. Early in infection, incoming viral ribonucleoproteins (vRNPs) are imported into the nucleus. Later, viral transcripts are exported from the nucleus, newly synthesized structural proteins are transported back into the nucleus and, finally, newly assembled vRNPs are exported. All these import and export steps, and, in particular the bidirectional traffic of vRNPs rely on the transport machinery of the cell, but are regulated both by viral and cellular factors. The viral M1 protein serves as the master organizer in determining the directionality of vRNP transport.
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页码:67 / 71
页数:5
相关论文
共 48 条
[1]   THE IMPORTANCE OF IMPORTIN [J].
ADAM, SA .
TRENDS IN CELL BIOLOGY, 1995, 5 (05) :189-191
[2]   STRUCTURE OF INFLUENZA-VIRUS RNP .1. INFLUENZA-VIRUS NUCLEOPROTEIN MELTS SECONDARY STRUCTURE IN PANHANDLE RNA AND EXPOSES THE BASES TO THE SOLVENT [J].
BAUDIN, F ;
BACH, C ;
CUSACK, S ;
RUIGROK, RWH .
EMBO JOURNAL, 1994, 13 (13) :3158-3165
[3]   TRANSCRIPTION ANTITERMINATION DURING INFLUENZA VIRAL TEMPLATE RNA-SYNTHESIS REQUIRES THE NUCLEOCAPSID PROTEIN AND THE ABSENCE OF A 5' CAPPED END [J].
BEATON, AR ;
KRUG, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (17) :6282-6286
[4]   ROLE OF THE M2 PROTEIN IN INFLUENZA-VIRUS MEMBRANE-FUSION - EFFECTS OF AMANTADINE AND MONENSIN ON FUSION KINETICS [J].
BRON, R ;
KENDAL, AP ;
KLENK, HD ;
WILSCHUT, J .
VIROLOGY, 1993, 195 (02) :808-811
[5]   INFLUENZA-VIRUS UNCOATING IN INFECTED-CELLS AND EFFECT OF RIMANTADINE [J].
BUKRINSKAYA, AG ;
VORKUNOVA, NK ;
KORNILAYEVA, GV ;
NARMANBETOVA, RA ;
VORKUNOVA, GK .
JOURNAL OF GENERAL VIROLOGY, 1982, 60 (MAY) :49-59
[6]  
Colman P.M., 1989, INFLUENZA VIRUSES, P175
[7]   STRUCTURE OF RIBONUCLEOPROTEIN OF INFLUENZA VIRUS [J].
COMPANS, RW ;
CONTENT, J ;
DUESBERG, PH .
JOURNAL OF VIROLOGY, 1972, 10 (04) :795-&
[8]   INFLUENZA VIRUS PROTEINS .1. ANALYSIS OF POLYPEPTIDES OF VIRION AND IDENTIFICATION OF SPIKE GLYCOPROTEINS [J].
COMPANS, RW ;
KLENK, HD ;
CALIGUIRI, LA ;
CHOPPIN, PW .
VIROLOGY, 1970, 42 (04) :880-+
[9]   IDENTIFICATION OF THE SEQUENCE RESPONSIBLE FOR THE NUCLEAR ACCUMULATION OF THE INFLUENZA-VIRUS NUCLEOPROTEIN IN XENOPUS OOCYTES [J].
DAVEY, J ;
DIMMOCK, NJ ;
COLMAN, A .
CELL, 1985, 40 (03) :667-675
[10]  
DWORETZKY SI, 1984, J CELL BIOL, V99, P2216