New biocidal N-halamine-PEG polymers

The synthesis and biocidal efficacies of two PEG-N-halamine polymers were reported. The N-halamines are classified as dichlorohydantoins and chloroimidazolidin-4-ones, which were attached to a methoxy-poly(ethylene glycol) terminated amine. A 1000 ppm solution of each N-halamine polymer was prepared in water and it was demonstrated that Staphylococcus aureus was inactivated (6 logs) when it was in contact with these polymeric solutions for ten minutes. The stability of these solutions was determined over prolonged periods of time, as well as the biocidal efficacies. These polymeric materials show commercial potential as surface active biocides if the poly(ethylene glycol) moiety can be anchored to a surface.