Synthesis of the C8-C15 segment of (+)-discodermolide

被引：26

作者：

Miyazawa, M ^{[1
]}

Oonuma, S ^{[1
]}

Maruyama, K ^{[1
]}

Miyashita, M ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Sci, Div Chem, Sapporo, Hokkaido 060, Japan

来源：

CHEMISTRY LETTERS | 1997年 / 12期

关键词：

D O I：

10.1246/cl.1997.1193

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Succeeding to the preceding paper, stereoselective synthesis of the C-8-C-15 segment of (+)-discodermolide (1), the marine natural product having the potent immunosuppressive activity, is described in which the contiguous asymmetric centers at C-11 and C-12 positions were stereospecifically constructed via the methylation of an epoxy alcohol with lithium dimethylcuprate.

引用

页码：1193 / 1194

页数：2

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