Indomethacin-containing nanoparticles derived from amphiphilic polynorbornene: A model ROMP-based drug encapsulation system

被引：60

作者：

Bertin, PA

Watson, KJ

Nguyen, ST ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Ctr Nanofabricat & Mol Self Assembly, Evanston, IL 60208 USA

来源：

MACROMOLECULES | 2004年 / 37卷 / 22期

关键词：

D O I：

10.1021/ma035741+

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A series of monodisperse amphiphilic diblock copolymers containing a high-density of covalently linked indomethacin as the hydrophobic block and pendant hexaethylene glycol monomethyl ether as the hydrophilic block have been synthesized from ring-opening metathesis polymerization (ROMP) using Cl-2(PCy3)(2)Ru = CHPh. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and H-1 NMR spectroscopy have been used to investigate the directed-assembly of these polynorbornene-based copolymers into polymeric nanoparticles in aqueous media as a function of copolymer composition, concentration, and degree of polymerization. The block copolymers formed micelle-like aggregates in the aqueous phase with mean diameters ranging from 993 +/- 270 nm to 94 +/- 14 nm by TEM. In general, the aggregate size decreased as the overall copolymer length decreased. After incubation in an acidic environment (PH = 3) at 37 degreesC for 48 h, 20% of the indomethacin was released from the nanoparticles.

引用

页码：8364 / 8372

页数：9

共 38 条

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