Gnetol as a potent tyrosinase inhibitor from genus Gnetum

被引：64

作者：

Ohguchi, K ^{[1
]}

Tanaka, T

Iliya, I

Ito, T

Iinuma, M

Matsumoto, K

Akao, Y

Nozawa, Y

机构：

[1] Gifu Int Inst Biotechnol, Gifu 5050116, Japan

[2] Gifu Prefectural Inst Hlth & Environm Sci, Gifu 5040838, Japan

[3] Gifu Pharmaceut Univ, Gifu 5025858, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 03期

关键词：

tyrosinase; melanin; gnetaceae; gnetol;

D O I：

10.1271/bbb.67.663

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 muM) was stronger than kojic acid (IC50, 139 muM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed melanin biosynthesis in murine B16 melanoma cells.

引用

页码：663 / 665

页数：3

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