Up-regulation of p27Kip1 correlates inversely with anchorage independent growth of human cancer cell lines

被引：22

作者：

Kawada, M

Uehara, Y

Mizuno, S

Yamori, T

Tsuruo, T

机构：

[1] Natl Inst Infect Dis, Dept Bioact Mol, Shinjuku Ku, Tokyo 162, Japan

[2] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Toshima Ku, Tokyo 170, Japan

[3] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 113, Japan

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1998年 / 89卷 / 02期

关键词：

human cancer; anchorage independence; cell cycle; p27(Kip1);

D O I：

10.1111/j.1349-7006.1998.tb00537.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the correlation between anchorage-independent growth and cell cycle-related molecules using 39 human cancer cell lines, They consisted of lung-, colon-, stomach-, breast-, ovarian-, brain-, renal- and melanoma-derived cell lines, Their anchorage-independent growth ability varied, but was not clearly related to the tissue of origin, There was a tendency for the levels of cyclin D1, cyclin E, cyclin A, p27, and p21 to show a tissue-dependent expression pattern. Statistical analysis revealed an inverse correlation of the p27 level with anchorage-independent growth (r=-0.456, P<0.01). Thus, the regulation of p27 is suggested to be linked to the anchorage independence of human cancer cells.

引用

页码：110 / 115

页数：6

共 24 条

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