The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria

被引：41

作者：

Nemajerova, A ^{[1
]}

Erster, S ^{[1
]}

Moll, UM ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Pathol, Stony Brook, NY 11794 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2005年 / 12卷 / 02期

关键词：

D O I：

10.1038/sj.cdd.4401526

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：197 / 200

页数：4

共 18 条

[1] Post-translational modifications and activation of p53 by genotoxic stresses [J].

Appella, E ;

Anderson, CW .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (10) :2764-2772

[2] The codon 72 polymorphic variants of p53 have markedly different apoptotic potential [J].

Dumont, P ;

Leu, JIJ ;

Della Pietra, AC ;

George, DL ;

Murphy, M .

NATURE GENETICS, 2003, 33 (03) :357-365

[3] In vivo mitochondrial p53 transloclation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation [J].

Erster, S ;

Mihara, M ;

Kim, RH ;

Petrenko, O ;

Moll, UM .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (15) :6728-6741

[4] Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain [J].

Gu, W ;

Roeder, RG .

CELL, 1997, 90 (04) :595-606

[5] Mutation of phosphoserine 389 affects p53 function in vivo [J].

Hao, MM ;

Lowy, AM ;

Kapoor, M ;

Deffie, A ;

Liu, G ;

Lozano, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) :29380-29385

[6] Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex [J].

Leu, JIJ ;

Dumont, P ;

Hafey, M ;

Murphy, ME ;

George, DL .

NATURE CELL BIOLOGY, 2004, 6 (05) :443-450

[7] Acetylation of p53 inhibits its ubiquitination by Mdm2 [J].

Li, MY ;

Luo, JY ;

Brooks, CL ;

Gu, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (52) :50607-50611

[8]

Liu L, 1999, MOL CELL BIOL, V19, P1202

[9] Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells [J].

Mahyar-Roemer, M ;

Fritzsche, C ;

Wagner, S ;

Laue, M ;

Roemer, K .

ONCOGENE, 2004, 23 (37) :6226-6236

[10] Death signal-induced localization of p53 protein to mitochondria - A potential role in apoptotic signaling [J].

Marchenko, ND ;

Zaika, A ;

Moll, UM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (21) :16202-16212

← 1 2 →