Study of the interaction between daunorubicin and human serum albumin, and the determination of daunorubicin in blood serum samples

被引：130

作者：

Jiang, CQ ^{[1
]}

Gao, MX ^{[1
]}

Meng, XZ ^{[1
]}

机构：

[1] Shandong Normal Univ, Dept Chem, Jinan 250014, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2003年 / 59卷 / 07期

关键词：

daunorubicin; human serum albumin; fluorescence quenching;

D O I：

10.1016/S1386-1425(02)00362-1

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The interactions between daunorubicin and human serum albumin (HSA) were studied using the spectrofluorimetric method. The binding constants of daunorubicin with HSA were obtained at different temperatures. The effects of various metal ions on the binding constants of daunorubicin with HSA were also studied. The optimum conditions of fluorometric determination of daunorubicin were studied and the developed method was successfully applied to the determination of daunorubicin in serum samples. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1605 / 1610

页数：6

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