Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

被引:53
作者
Almeida Montes, Luis Guillermo [1 ,2 ]
Ricardo-Garcell, Josefina [2 ]
Barajas De la Torre, Lazaro [3 ]
Prado Alcantara, Hugo
Martinez Garcia, Reyna Beatriz
Fernandez-Bouzas, Antonio [4 ]
Avila Acosta, David [4 ]
机构
[1] Univ Nacl Autonoma Mexico, Dept Invest, Ctr Estatal Salud Mental, Serv Salud Estado Queretaro, Queretaro, Mexico
[2] Univ Nacl Autonoma Mexico, Dept Invest, Inst Neurobiol, Queretaro, Mexico
[3] Inst Tecnol & Estudios Super Monterrey, Queretaro, Mexico
[4] Univ Nacl Autonoma Mexico, Dept Neuroradiol, Inst Neurobiol, Queretaro, Mexico
来源
JOURNAL OF PSYCHIATRY & NEUROSCIENCE | 2010年 / 35卷 / 04期
关键词
VOXEL-BASED MORPHOMETRY; DEFICIT/HYPERACTIVITY DISORDER; DOPAMINE TRANSPORTER; VOLUMETRIC-ANALYSIS; BASAL GANGLIA; MRI; ABNORMALITIES; COMORBIDITY; VALIDATION; CHILDREN;
D O I
10.1503/jpn.090099
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Magnetic resonance imaging (MRI) studies have shown decreased caudate volumes in individuals with attention deficit hyperactivity disorder (ADHD). However, most of these studies have been carried out in male children. Very little research has been done in adults, and the results obtained in children are difficult to extrapolate to adults. We sought to compare the volume of the caudate of adults with ADHD with that of healthy controls; we also compared these volumes between men and women. Methods: We performed an MRI scan on 20 adults with ADHD (10 men and 10 women) aged 25-35 years and 20 healthy controls matched by age and sex. We used voxel-based morphometry with the DARTEL algorithm for image analyses. We used the specifically designed Friederichsen, Almeida, Serrano, Cortes Test (FASCT) to measure the severity of ADHD; both the self-reported (FASCT-SR) and the observer (FASCT-O) versions were used. Results: The statistical parametric map showed a smaller region with low grey matter volume and a smaller concentration of grey matter in this region of the right caudate in ADHD patients than in health controls, both in the entire sample and within each sex. There was a significant correlation between the volume of this region of the caudate with the number of DSM IV-TR criteria, as well as with the total scores and most of the factors of the FASCT-SR and FASCT-O scales. A separate correlation analysis by sex gave similar results. Limitations: The study design was cross-sectional. Conclusion: The region of the right caudate with low grey matter volume was smaller in adults with ADHD in both sexes and was correlated with ADHD severity.
引用
收藏
页码:238 / 246
页数:9
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