The quest for an AIDS vaccine:: is the CD8+ T-cell approach feasible?

被引：111

作者：

McMichael, A

Hanke, T

机构：

[1] MRC Human Immunology Unit, Weatherall Inst. of Molec. Medicine, John Radcliffe Hospital

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1038/nri779

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.

引用

页码：283 / 291

页数：9

共 126 条

[1] High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection
Ahlers, JD
Belyakov, IM
Thomas, EK
Berzofsky, JA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (11) : 1677 - 1685
[2] ALCHELE P, 1995, J EXP MED, V182, P261
[3] Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen
Allen, TM
Vogel, TU
Fuller, DH
Mothé, BR
Steffen, S
Boyson, JE
Shipley, T
Fuller, J
Hanke, T
Sette, A
Altman, JD
Moss, B
McMichael, AJ
Watkins, DI
[J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (09) : 4968 - 4978
[4] Phenotypic analysis of antigen-specific T lymphocytes
Altman, JD
Moss, PAH
Goulder, PJR
Barouch, DH
McHeyzerWilliams, MG
Bell, JI
McMichael, AJ
Davis, MM
[J]. SCIENCE, 1996, 274 (5284) : 94 - 96
[5] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
Amara, RR
Villinger, F
Altman, JD
Lydy, SL
O'Neil, SP
Staprans, SI
Montefiori, DC
Xu, Y
Herndon, JG
Wyatt, LS
Candido, MA
Kozyr, NL
Earl, PL
Smith, JM
Ma, HL
Grimm, BD
Hulsey, ML
Miller, J
McClure, HM
McNicholl, JM
Moss, B
Robinson, HL
[J]. SCIENCE, 2001, 292 (5514) : 69 - 74
[6] HIV-specific CD8+ T cells produce antiviral cytokines but are impaired in cytolytic function
Appay, V
Nixon, DF
Donahoe, SM
Gillespie, GMA
Dong, T
King, A
Ogg, GS
Spiegel, HML
Conlon, C
Spina, CA
Havlir, DV
Richman, DD
Waters, A
Easterbrook, P
McMichael, AJ
Rowland-Jones, SL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (01) : 63 - 75
[7] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
Barouch, DH
Santra, S
Schmitz, JE
Kuroda, MJ
Fu, TM
Wagner, W
Bilska, M
Craiu, A
Zheng, XX
Krivulka, GR
Beaudry, K
Lifton, MA
Nickerson, CE
Trigona, WL
Punt, K
Freed, DC
Guan, LM
Dubey, S
Casimiro, D
Simon, A
Davies, ME
Chastain, M
Strom, TB
Gelman, RS
Montefiori, DC
Lewis, MG
Emini, EA
Shiver, JW
Letvin, NL
[J]. SCIENCE, 2000, 290 (5491) : 486 - 492
[8] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
Barouch, DH
Kunstman, J
Kuroda, MJ
Schmitz, JE
Santra, S
Peyerl, FW
Krivulka, GR
Beaudry, K
Lifton, MA
Gorgone, DA
Montefiori, DC
Lewis, MG
Wolinsky, SM
Letvin, NL
[J]. NATURE, 2002, 415 (6869) : 335 - 339
[9] Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination
Barouch, DH
Santra, S
Kuroda, MJ
Schmitz, JE
Plishka, R
Buckler-White, A
Gaitan, AE
Zin, R
Nam, JH
Wyatt, LS
Lifton, MA
Nickerson, CE
Moss, B
Montefiori, DC
Hirsch, VM
Letvin, NL
[J]. JOURNAL OF VIROLOGY, 2001, 75 (11) : 5151 - 5158
[10] Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques
Belyakov, IM
Hel, Z
Kelsall, B
Kuznetsov, VA
Ahlers, JD
Nacsa, J
Watkins, DI
Allen, TM
Sette, A
Altman, J
Woodward, R
Markham, PD
Clements, JD
Franchini, G
Strober, W
Berzofsky, JA
[J]. NATURE MEDICINE, 2001, 7 (12) : 1320 - 1326

← 1 2 3 4 5 6 7 8 9 10 →