Optical detection of single molecules in nanofluidic chips

被引：2

作者：

Parikesit, GOF ^{[1
]}

Kutchoukov, VG ^{[1
]}

van Oel, W ^{[1
]}

Lung, GL ^{[1
]}

Bossche, A ^{[1
]}

Young, IT ^{[1
]}

Garini, Y ^{[1
]}

机构：

[1] Delft Univ Technol, Quantitat Imaging Grp, NL-2628 CJ Delft, Netherlands

来源：

NANOENGINEERING: FABRICATION, PROPERTIES, OPTICS, AND DEVICES | 2004年 / 5515卷

关键词：

optical detection; nanofluidics; single molecules; lab on a chip;

D O I：

10.1117/12.559386

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are performed using optical imaging as well as metal microelectrodes. The ultimate goal is to get high spatial and spectral resolutions that can lead to molecular identification.

引用

页码：109 / 116

页数：8

共 6 条

[1]

Hughes M.P., 2003, NANOELECTROMECHANICS

[2]

KUTCHOUKOV VG, 2004, IN PRESS P EUROSENSO

[3]

Levenson R., 2000, SPECTRAL IMAGING MIC

[4]

NGUYEN NT, 2002, FUNDAMENTALS APPL MI

[5] Single-target molecule detection with nonbleaching multicolor optical immunolabels [J].

Schultz, S ;

Smith, DR ;

Mock, JJ ;

Schultz, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) :996-1001

[6]

Zander C., 2002, SINGLE MOL DETECTION, DOI DOI 10.1002/3527600809

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