Highly enantioselective asymmetric hydrogenation of β-acetamido dehydroamino acid derivatives using a three-hindered quadrant rhodium catalyst

被引：71

作者：

Wu, HP ^{[1
]}

Hoge, G ^{[1
]}

机构：

[1] Pfizer Inc, Ann Arbor, MI 48105 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 20期

关键词：

D O I：

10.1021/ol048386w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A previously reported three-hindered quadrant chiral ligand and its corresponding rhodium complex provide high enantioselectivity for the asymmetric hydrogenation of beta-acetamido dehydroamino acid substrates. Both (E)- and (Z)-substrates are hydrogenated with high enantioselectivity in all of the reported examples. Asymmetric hydrogenation of a cyclic beta-acetamido dehydroamino acid substrate in 85% ee is also reported.

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页码：3645 / 3647

页数：3

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