Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development

被引：196

作者：

Page-McCaw, A ^{[1
]}

Serano, J ^{[1
]}

Santé, JM ^{[1
]}

Rubin, GM ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cellular Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 01期

关键词：

D O I：

10.1016/S1534-5807(02)00400-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The matrix metalloproteinase (MMP) family is heavily implicated in many diseases, including cancer. The developmental functions of these genes are not clear, however, because the >20 mammalian MMPs can be functionally redundant. Drosophila melanogaster has only two MMPs, which are expressed in embryos in distinct patterns. We created mutations in both genes: Mmp1 mutants have defects in larval tracheal growth and pupal head eversion, and Mmp2 mutants have defects in larval tissue histolysis and epithelial fusion during metamorphosis; neither is required for embryonic development. Double mutants also complete embryogenesis, and these represent the first time, to our knowledge, that all MMPs have been disrupted in any organism. Thus, MMPs are not required for Drosophila embryonic development, but, rather, for tissue remodeling.

引用

页码：95 / 106

页数：12

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