Regulation of mitochondrial membrane premeabilization by BCL-2 family proteins and caspases

被引：225

作者：

Breckenridge, DG ^{[1
]}

Xue, D ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.ceb.2004.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria play an important role in the integration and transmission of cell death signals, activating caspases and other cell death execution events by releasing apoptogenic proteins from the intermembrane space. The BCL-2 family of proteins localize (or can be targeted) to mitochohdria and regulate the permeability of the mitochondrial outer membrane to these apoptotic factors. Recent evidence suggests that multiple mechanisms may regulate the release of mitochondrial factors, some of which depend on the action of caspases.

引用

页码：647 / 652

页数：6

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