Myosin II function in non-muscle cells

Amongst the remarkable variety of motility that cells display, cytokinesis (cell division) is particularly striking. Dramatic changes in cell shape occur before, during and after cytokinesis. Myosin II is implicated in the 'rounding up' of cells prior to cytokinesis, and is essential in the formation of the contractile cleavage furrow during cytokinesis. Now it appears that myosin II plays a role in all stages of cytokinesis, as a recent report((1)) suggests that myosin II drives post-mitotic cell spreading. A similar type of motile mechanism operating in cell spreading may occur in other cell types in other situations.