Saponins from stems and leaves of Panax ginseng prevent obesity via regulating thermogenesis, lipogenesis and lipolysis in high-fat diet induced obese C57BL/6 mice

被引：63

作者：

Chen, Guilin ^{[1
]}

Li, Haijun ^{[2
]}

Zhao, Yan ^{[1
]}

Zhu, Hongyan ^{[1
]}

Cai, Enbo ^{[1
]}

Gao, Yugang ^{[1
]}

Liu, Shuangli ^{[1
]}

Yang, He ^{[1
]}

Zhang, Lianxue ^{[1
]}

机构：

[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[2] Jilin Univ, Hosp 1, Inst Translat Med, Changchun, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2017年 / 106卷

关键词：

Anti-obesity; Saponins; Panax ginseng; C57BL/6; mice; Haematoxylin and eosin; RT-PCR; KOREAN RED GINSENG; CONJUGATED LINOLEIC-ACID; IMPROVES INSULIN SENSITIVITY; INHIBITING ANGIOGENESIS; ENERGY-EXPENDITURE; BETA-OXIDATION; C/EBP-ALPHA; PPAR-GAMMA; IDENTIFICATION; ACYLCARNITINE;

D O I：

10.1016/j.fct.2017.06.012

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

In this study, high-fat diet (HFD)-induced obesity in mouse model was used to evaluate the dietary effect of saponins from stems and leaves of Panax ginseng (SLG), and to explore its mechanism of action in producing anti-obesity effects. The results indicate that SLG showed significant anti-obesity effects in diet -induced obese mice, represented by decreased serum levels of free fatty acids (FFA), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL)-cholesterol, glucose, leptin and insulin, as well as a reduction in overall body and liver weight, epididymal adipose tissue weight, and food efficiency, and inhibition of abnormal increases in acyl carnitine levels normally caused by an HFD. Additionally, the down-regulated expression of PPAR gamma, FAS, CD36, FATP2 and up-regulated expression of CPT-1, UCP-2, PPAR alpha, HSL, and ATGL in liver tissue was induced by SLG. In addition, the SLG groups showed decreased PPAR gamma, aP2 and leptin mRNA levels and increased expression of PPAR alpha, PGC-1 alpha, UCP-1 and UCP-3 genes in adipose tissues, compared with the HFD group. In short, SLG may play a key role in producing anti obesity effects in mice fed an HFD, and its mechanism may be related to regulation of thermogenesis, lipogenesis and lipolysis. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：393 / 403

页数：11

共 54 条

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Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women [J].