Terahertz dielectric assay of solution phase protein binding

被引：59

作者：

Chen, Jing-Yin ^{[1
]}

Knab, J. R. ^{[1
]}

Ye, Shuji ^{[1
]}

He, Yunfen ^{[1
]}

Markelz, A. G. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA

来源：

APPLIED PHYSICS LETTERS | 2007年 / 90卷 / 24期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.2748852

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The authors demonstrate a method for rapid determination of protein-ligand binding on solution phase samples using terahertz dielectric spectroscopy. Measurements were performed using terahertz time domain spectroscopy on aqueous solutions below the liquid-solid transition for water. Small ligand binding sensitivity was demonstrated using triacetylglucosamine and hen egg white lysozyme with a decrease in dielectric response with binding. The magnitude of the change increases with frequency. (c) 2007 American Institute of Physics.

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页数：3

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