Control of transcription by pontin and reptin

被引：119

作者：

Gallant, Peter ^{[1
]}

机构：

[1] Univ Zurich, Inst Zool, CH-8057 Zurich, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 04期

关键词：

D O I：

10.1016/j.tcb.2007.02.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pontin and Reptin are two closely related members of the AAA+ family of DNA helicases. They have roles in diverse cellular processes, including the response to DNA double-strand breaks and the control of gene expression. The two proteins share residence in different multiprotein complexes, such as the Tip60, Ino80, SRCAP and Uri1 complexes in animals, which are involved (directly or indirectly) in transcriptional regulation, but they also function independently from each other. Both Reptin and Pontin repress certain transcriptional targets of Myc, but only Reptin is required for the repression of specific beta-catenin and nuclear factor-KB targets. Here, I review recent studies that have addressed the mechanisms of transcriptional control by Pontin and Reptin.

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页码：187 / 192

页数：6

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