Structural biology - The ribosome is a ribozyme

被引:234
作者
Cech, TR [1 ]
机构
[1] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
关键词
D O I
10.1126/science.289.5481.878
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:878 / 879
页数:2
相关论文
共 15 条
  • [1] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution
    Ban, N
    Nissen, P
    Hansen, J
    Moore, PB
    Steitz, TA
    [J]. SCIENCE, 2000, 289 (5481) : 905 - 920
  • [2] Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
    Ban, N
    Nissen, P
    Hansen, J
    Capel, M
    Moore, PB
    Steitz, TA
    [J]. NATURE, 1999, 400 (6747) : 841 - 847
  • [3] X-ray crystal structures of 70S ribosome functional complexes
    Cate, JH
    Yusupov, MM
    Yusupova, GZ
    Earnest, TN
    Noller, HF
    [J]. SCIENCE, 1999, 285 (5436) : 2095 - 2104
  • [4] Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution
    Clemons, WM
    May, JLC
    Wimberly, BT
    McCutcheon, JP
    Capel, MS
    Ramakrishnan, V
    [J]. NATURE, 1999, 400 (6747) : 833 - 840
  • [5] Crystal structure of a hepatitis delta virus ribozyme
    Ferré-D'Amaré, AR
    Zhou, KH
    Doudna, JA
    [J]. NATURE, 1998, 395 (6702) : 567 - 574
  • [6] Unusual dynamics and pK(a) shift at the active site of a lead-dependent ribozyme
    Legault, P
    Pardi, A
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (28) : 6621 - 6628
  • [7] A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center
    Muth, GW
    Ortoleva-Donnelly, L
    Strobel, SA
    [J]. SCIENCE, 2000, 289 (5481) : 947 - 950
  • [8] General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
    Nakano, S
    Chadalavada, DM
    Bevilacqua, PC
    [J]. SCIENCE, 2000, 287 (5457) : 1493 - 1497
  • [9] The structural basis of ribosome activity in peptide bond synthesis
    Nissen, P
    Hansen, J
    Ban, N
    Moore, PB
    Steitz, TA
    [J]. SCIENCE, 2000, 289 (5481) : 920 - 930
  • [10] SECONDARY STRUCTURE MODEL FOR 23S RIBOSOMAL-RNA
    NOLLER, HF
    KOP, J
    WHEATON, V
    BROSIUS, J
    GUTELL, RR
    KOPYLOV, AM
    DOHME, F
    HERR, W
    STAHL, DA
    GUPTA, R
    WOESE, CR
    [J]. NUCLEIC ACIDS RESEARCH, 1981, 9 (22) : 6167 - 6189