Uric acid transport and disease

被引：748

作者：

So, Alexander ^{[3
]}

Thorens, Bernard ^{[1
,2
]}

机构：

[1] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, Dept Physiol, CH-1015 Lausanne, Switzerland

[3] Univ Lausanne, Dept Musculoskeletal Med, Serv Rhumatol, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

ORGANIC ANION TRANSPORTER; NITRIC-OXIDE SYNTHASE; URATE EFFLUX TRANSPORTER; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; INSULIN-RESISTANCE; RENAL HYPOURICEMIA; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;

D O I：

10.1172/JCI42344

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironrnent. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, insulin resistance, and diabetes. We discuss here the biology of urate metabolism and its role in disease. We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development.

引用

页码：1791 / 1799

页数：9

共 104 条

[1] URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].

AMES, BN ;

CATHCART, R ;

SCHWIERS, E ;

HOCHSTEIN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862

[2] The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus [J].

Anzai, N ;

Miyazaki, H ;

Noshiro, R ;

Khamdang, S ;

Chairoungdua, A ;

Shin, HJ ;

Enomoto, A ;

Sakamoto, S ;

Hirata, T ;

Tomita, K ;

Kanai, Y ;

Endou, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (44) :45942-45950

[3] Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans [J].

Anzai, Naohiko ;

Ichida, Kimiyoshi ;

Jutabha, Promsuk ;

Kimura, Toru ;

Babu, Ellappan ;

Jin, Chun Ji ;

Srivastava, Sunena ;

Kitamura, Kenichiro ;

Hisatome, Ichiro ;

Endou, Hitoshi ;

Sakurai, Hiroyuki .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (40) :26834-26838

[4] New insights into renal transport of urate [J].

Anzai, Naohiko ;

Kanai, Yoshikatsu ;

Endou, Hitoshi .

CURRENT OPINION IN RHEUMATOLOGY, 2007, 19 (02) :151-157

[5] Identification and characterization of human glucose transporter-like protein-9 (GLUT9) - Alternative splicing alters trafficking [J].

Augustin, R ;

Carayannopoulos, MO ;

Dowd, LO ;

Phay, JE ;

Moley, JF ;

Moley, KH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (16) :16229-16236

[6] When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid [J].

Bagnati, M ;

Perugini, C ;

Cau, C ;

Bordone, R ;

Albano, E ;

Bellomo, G .

BIOCHEMICAL JOURNAL, 1999, 340 :143-152

[7] Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13) [J].

Bahn, Andrew ;

Hagos, Yohannes ;

Reuter, Stefan ;

Balen, Daniela ;

Brzica, Hrvoje ;

Krick, Wolfgang ;

Burckhardt, Birgitta C. ;

Sabolic, Ivan ;

Burckhardt, Gerhard .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (24) :16332-16341

[8] Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux [J].

Bakhiya, N ;

Bahn, A ;

Burckhardt, G ;

Wolff, NA .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2003, 13 (05) :249-256

[9] Mutations in the SLC2A9 Gene Cause Hyperuricosuria and Hyperuricemia in the Dog [J].

Bannasch, Danika ;

Safra, Noa ;

Young, Amy ;

Karmi, Nili ;

Schaible, R. S. ;

Ling, G. V. .

PLOS GENETICS, 2008, 4 (11)

[10] The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver [J].

Beer, Nicola L. ;

Tribble, Nicholas D. ;

McCulloch, Laura J. ;

Roos, Charlotta ;

Johnson, Paul R. V. ;

Orho-Melander, Marju ;

Gloyn, Anna L. .

HUMAN MOLECULAR GENETICS, 2009, 18 (21) :4081-4088

← 1 2 3 4 5 6 7 8 9 10 →