Notch and cancer: Best to avoid the ups and downs

被引：102

作者：

Maillard, I

Pear, WS

机构：

[1] Univ Penn, Inst Med & Engn, Div Hematol Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Med & Engn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Inst Med & Engn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CANCER CELL | 2003年 / 3卷 / 03期

关键词：

D O I：

10.1016/S1535-6108(03)00052-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Notch pathway is known for its multiple important roles in development and tissue homeostasis, and it can be subverted during oncogenic transformation. Two recent studies add to our understanding of Notch in cancer biology in contrasting ways, by showing novel mechanisms of Notch pathway activation in cancer cells, and by indicating that in some circumstances, Notch can behave as a tumor suppressor.

引用

页码：203 / 205

页数：3

共 21 条

[1] Notch signaling in cancer
Allenspach, EJ
Maillard, I
Aster, JC
Pear, WS
[J]. CANCER BIOLOGY & THERAPY, 2002, 1 (05) : 466 - 476
[2] An invitation to T and more: Notch signaling in lymphopoiesis
Allman, D
Punt, JA
Izon, DJ
Aster, JC
Pear, WS
[J]. CELL, 2002, 109 : S1 - S11
[3] Notch signaling in leukemia
Aster, JC
Pear, WS
[J]. CURRENT OPINION IN HEMATOLOGY, 2001, 8 (04) : 237 - 244
[4] Interaction between wingless and notch signaling pathways mediated by dishevelled
Axelrod, JD
Matsuno, K
ArtavanisTsakonas, S
Perrimon, N
[J]. SCIENCE, 1996, 271 (5257) : 1826 - 1832
[5] Hedgehog signaling and human disease
Bale, AE
[J]. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2002, 3 : 47 - 65
[6] Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2
Capobianco, AJ
Zagouras, P
Blaumueller, CM
ArtavanisTsakonas, S
Bishop, JM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (11) : 6265 - 6273
[7] A common human skin tumour is caused by activating mutations in β-catenin
Chan, EF
Gat, U
McNiff, JM
Fuchs, E
[J]. NATURE GENETICS, 1999, 21 (04) : 410 - 413
[8] TAN-1, THE HUMAN HOMOLOG OF THE DROSOPHILA NOTCH GENE, IS BROKEN BY CHROMOSOMAL TRANSLOCATIONS IN T-LYMPHOBLASTIC NEOPLASMS
ELLISEN, LW
BIRD, J
WEST, DC
SORENG, AL
REYNOLDS, TC
SMITH, SD
SKLAR, J
[J]. CELL, 1991, 66 (04) : 649 - 661
[9] Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
Fryer, CJ
Lamar, E
Turbachova, I
Kintner, C
Jones, KA
[J]. GENES & DEVELOPMENT, 2002, 16 (11) : 1397 - 1411
[10] Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing
Glise, B
Jones, DL
Ingham, PW
[J]. DEVELOPMENTAL BIOLOGY, 2002, 248 (01) : 93 - 106

← 1 2 3 →